Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
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چکیده
منابع مشابه
Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as us...
متن کاملVinca Alkaloids
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There ar...
متن کاملRiboflavin-mediated photosensitization of Vinca alkaloids distorts drug sensitivity assays.
Poor reproducibility of cytotoxicity tests with Vinca alkaloids has frequently been reported. A commonly presumed light sensitivity of the drugs could not be confirmed. However, we found that they are photosensitized by riboflavin (vitamin B2), an obligatory component of cell culture media. Light of wavelengths below 500 nm triggered rapid photoreactions of riboflavin with vinblastine, vincrist...
متن کاملRiboflavin-mediated Photosensitization of Vinca Alkaloids Distorts Drug Sensitivity Assays1
Poor reproducibility of cytotoxicity tests with Vinca alkaloids has fre quently been reported. A commonly presumed light sensitivity of the drugs could not be confirmed. However, we found that they are photo sensitized by riboflavin (vitamin li.i, an obligatory component of cell culture media. Light of wavelengths below 500 nm triggered rapid photoreactions of riboflavin with vinblastine, \ im ...
متن کاملNovel transdermal drug delivery systems
Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...
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ژورنال
عنوان ژورنال: Current Topics in Medicinal Chemistry
سال: 2015
ISSN: 1568-0266
DOI: 10.2174/1568026615666150414120547